作者= Takiguchi Shinichiro Makita Kai,藤泽隆X。,Nishitani Shota,但厉害TITLE =鼻内催产素对神经的影响在儿童和青少年奖励处理反应性依恋障碍:一个随机对照试验在儿童和青少年精神病学杂志=前沿体积= 1年= 2023 URL = //www.thespel.com/articles/10.3389/frcha.2022.1056115 DOI = 10.3389 /抽象frcha.2022.105611雷竞技rebat5 ISSN = 2813 - 4540 =反应性依恋障碍(RAD)与社会和少言寡语的/抑制行为和神经反应降低到奖励。儿童和青少年与RAD显示异常的依恋行为,和现有的心理疗法是难以维护;因此,药理干预援助和促进治疗的反应是必要的。催产素(OT)政府是促进奖励功能。我们调查是否一次性鼻内无法管理改进的神经反应奖励处理期间RAD患者与健康对照组相比。与RAD 24男性儿童和青少年(10 - 18岁)和27岁,sex-matched正常个体(- 17岁)被包含在这个随机,双盲,安慰剂对照,交叉,功能性磁共振成像研究。后一个鼻内OT (24 IU)或安慰剂,神经反应了使用货币奖励任务。RAD组不显著增加主观动机得分,显著增强激活右侧额中回,并降低激活在右侧中央前回金钱奖励的任务。活动增加的额外的分析揭示了两国尾状在一个更宽松的阈值。 Under placebo conditions, the severity of internalizing problems in patients with RAD was negatively correlated with ventral striatal activity. Moreover, the effect of OT on ventral striatum activity was positively associated with the severity of internalizing problems in patients with RAD. Intranasal OT administration enhanced activity in the reward pathway in male children and adolescents with RAD, suggesting that exogenous OT promotes reward processing and reward-related motivational behavior in these individuals. Further investigation is needed to fully understand the neural mechanisms of intranasal OT and identify novel targets for pediatric cases with RAD.Clinical trial registration: UMIN-CTR; UMIN000013215. URL: https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000015419