作者=周鑫,王Baohong Demkowicz帕特里克·C。,约翰逊Jethro年代。、陈Yanfei Spakowicz丹尼尔·J。周燕郊,多赛特Yair陈雷,Sodergren艾丽卡,Kuchel乔治·A。魏因斯托克,乔治·m . TITLE =口腔的探索性研究和粪便微生物在人类衰老期刊健康Frontiers in aging体积= = 3 = 2022年URL = https://www.frontiersin.or雷竞技rebatg/articles/10.3389/fragi.2022.1002405 DOI = 10.3389 /抽象fragi.2022.1002405 ISSN = 2673 - 6217 =越来越多的证据表明已经联系一个改变宿主粪便微生物组成与健康状况、常见的慢性疾病,制度化在脆弱的老年人。然而,较少的研究描述了微生物变化在健康老年人没有混淆的疾病或条件,以及老化的影响微生物在不同的身体网站仍然是未知的。使用16 s核糖体RNA基因测序,我们重建口腔的构成和粪便微生物在年轻(23-32;意味着= 25岁)和老年(69 - 94;意味着= 77岁)健康的社区研究对象。身体在这两个网站,我们确定了小细菌变化操作分类单元(辣子鸡)年轻的和年长的科目。然而,占主导地位的细菌物种的组成健康老年群体的微生物组没有明显不同于年轻的群体,这表明占主导地位的细菌种类与健康老龄化相对稳定。 In addition, the relative abundance of potentially pathogenic genera, such as Rothia and Mycoplasma, was enriched in the oral microbiome of the healthy older group relative to the young cohort. We also identified several OTUs with a prevalence above 40% and some were more common in young and others in healthy older adults. Differences with aging varied for oral and fecal samples, which suggests that members of the microbiome may be differentially affected by aging in a tissue-specific fashion. This is the first study to investigate both oral and fecal microbiomes in the context of human aging, and provides new insights into interactions between aging and the microbiome within two different clinically relevant sites.