阿齐兹萨玛,作者=汗哈菲兹·Ullah Maheen Safirah,汗Ikramullah, Andleeb Mehwish,尤尼斯希娜,海德尔萨贾德,海德尔Adnan,艾克塔穆罕默德•赛义德Shafqat赛义德·萨尔曼TITLE = Superporous丙烯酸和甲灭酸:HPMC水凝胶配方,描述和优化中心合成设计杂志=生物工程和生物技术前沿体积= 10年= 2022 URL = //www.thespel.com/articles/10.3389/fbioe.2022.1057627 DOI = 10.3389 /抽象fbioe.2022.1057627 ISSN = 2296 - 4185 =该研究的目的是设计Sup雷竞技rebaterporous水凝胶(sph)甲灭酸(MA)收购MA的持续行动。甲灭酸的superporous水凝胶是由采用气吹法制定。中心复合旋转设计(CCRD)应用于优化独立制定的影响因素,比如丙烯酸(AC)、HPMC和甘油(g) /因变量孔隙度、粘度、药物含量和superporous水凝胶的溶胀比水,磷酸缓冲(pH值6.8)和0.1 n盐酸(pH值1.2)。空隙率等特点,表面形态通过扫描电子显微镜(SEM)和体外药物释放研究治理以及理化分析,傅里叶变换红外光谱(FTIR)、差示扫描量热法(DSC)和评价统计采用方差分析。比较镇痛活性优化superporous水凝胶配方SPH17还用尾巴轻轻法分析。傅里叶变换红外光谱和差示扫描量热法研究批准之间的物理相容性聚合物和药物。指定的扫描电镜研究显微照相的了解配方形成的结构组成的毛孔,纤维和drug-hole总量。superporous水凝胶被检测到低密度时表示密度低于0.75 g / cc。聚合物和交联剂的浓度下降造成的空隙率增加superporous水凝胶配方。优化配方SPH 17表现出高度持续释放马10 h的0.1 N盐酸和磷酸缓冲媒体(66.6%)。 The non-fickian release of drug revealed the coupling of the diffusion and polymer relaxation mechanism of the drug release from the formulations. The obtained outcomes suggested that analgesic effect of SPH 17 was significantly (p < 0.05) higher than that of simple suspension of mefenamic acid and total analgesic effect duration for superporous hydrogel was also doubled as compared to the duration of analgesic effect produced by drug suspension. The successfully formulated SPH with HPMC K100M as a gelling agent had sustained the action of the mefenamic acid (MF) by improving its poor solubility and permeability. The introduction of inter-penetrating polymeric network (acrylic acid) using glycerol as a cross linker impart increased residence time to superporous hydrogels which ultimately enhanced the feasibility of using superporous hydrogel as oral sustained release devices particularly for gastric retention.